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In 1978, London-based journalist George Markov
He wrote articles criticizing the then communist authorities
Bulgaria positioned on the bus cease close to Waterloo station. A person, most likely a Bulgarian undercover agent, brushed up towards her, apparently. CS508 PAST PAPERS

Inadvertently, the umbrella hit him. Markov felt extreme ache, and
Inside just a few hours he began getting weak. excessive temperature, vomiting and so forth.
Extreme signs seem instantly. He died two days later.
Police investigators discovered a small pierced particle in Marco’s leg. CS508 PAST PAPERS

These particles comprise a small quantity of resin, which is a extremely poisonous molecule other than
Seeds of the tropical castor bean, Rhizome communis. These seeds have already been used
For hundreds of years as a supply of castor oil, a pure product beforehand frequent
It was given to youngsters to “cleanse” the digestive system and is now used within the plastics trade. Poison is a protein that isn’t current in oil, folks found
This difficult means is a kind of toxins that any organism can produce. CS508 PAST PAPERS
Ricin kills cells by blocking protein synthesis. Extra particularly, it stimulates the mutation and cleavage of one of many massive RNA molecules that make up a eukaryotic.

Ribosomes, the “workshop” of protein synthesis. Proteins are the principle phenotype
Genetic kind of expression – Genetic info is encoded within the DNA of a cell. ricin
Inhibits the power of a cell to specific the genotype as a phenotype via protein synthesis, so poisonous cells don’t survive.

 

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