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The primary broadly used scoring scheme for modified amino acids was developed Margaret Dahoff and her colleagues within the Seventies [46]. In your protein evolutionary mannequin Tahf entails observing how pairs of amino acids differ. Charges, that’s, laid out otherwise. For instance, as proven in Desk 2.2, lysine (Ok).
The physico-chemical relative is 37 instances extra prone to change than arginine (R). Chemically very differentiated leucine (L, fig. 4). Apart from the physico-chemical similarity, the speed of amino acid conversion varies with time.
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